Tissue Plasminogen Activator
Stroke Services
Tissue Plasminogen Activator
What is Tissue Plasminogen Activator (t-PA)?
Some people who are having an ischemic stroke can benefit from an injection of a recombinant tissue plasminogen activator (TPA), also called alteplase, usually given through a vein in the arm. This drug restores blood flow by dissolving the blood clot causing your stroke, and it may help people who have had strokes recover more fully. The doctor will consider certain risks, such as potential bleeding in the brain, to determine if TPA is the most appropriate treatment.
What is the Timeframe for Giving this Medicine?
The US Food and Drug Administration (FDA) approved IV t-PA for acute ischemic stroke in 1996. The FDA has approved the administration of this medication within three (3) hours of symptom onset. However, some physicians have given this medicine within four and one-half (4 ½) hours of symptom onset.
What is the Dose?
Total dose is 0.9 mg/kg (Maximum of 90 mg)
• 10% of the IV bolus is given over one minute
• The remaining 90% is given in an IV infusion over 60 minutes (1 hour)
Are there any Containdications?
Yes, there are several contraindications that would rule-out a patient from receiving t-PA. The physician will assess the patient and determine if the patient is a candidate to receive t-PA.